This paper examines Thai author Prabda Yoon’s Basement Moon, a 2018 science fictional novel that embodies the belief that art and science can play a vital role in triggering critical consciousness that keeps alive the spirit of dissent. A close reading of the novel also reveals that it mirrors several key concepts and ideas promoted by Gramsci pertaining to power relations between the ruling class and those under them and the educational roles of art and science. Of great significance is that this novel is exemplary of an innovative mode of political fiction in its employment of key posthumanist ideas that challenge human aspiration for absolute power and control. In discussing Basement Moon, I draw on Antonio Gramsci’s theory of hegemony as well as relevant literature in dystopia, posthumanism and metafiction.